The story follows a man (Domhnall Gleeson) with the ability to travel back in time who eventually meets the girl of his dreams.
McAdams takes over for Zooey Deschanel who was attached to star as the female lead
Bill Nighy, Tom Hollander, Margot Robbie, Lydia Wilson and Vanessa Kirby are set to co-star.
Richard Curtis ("Love Actually") directs from his script.
Tim Bevan, Eric Fellner, Liza Chasin and Amelia Granger are producing.
Once her work there is done, McAdams will shoot Anton Corbijn's new thriller A Most Wanted Man which begins production in September.
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