First performed in '07 the show revolves around a family's buried pains and present conflicts after its patriarch dies. Meryl Streep would play the drug-addicted matriarch, while Julia Roberts would play the eldest daughter who is estranged from her adulterous husband.
Cooper will play the brother-in-law of Streep's character.
British actress Andrea Riseborough ("W.E.") is in talks to star as Karen in the movie.
John Wells will direct the film from a screenplay adapted by Letts.
Harvey Weinstein and Jean Doumanian will produce the pic.
Shooting kicks off in August.
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