First performed in '07 the show revolves around a family's buried pains and present conflicts after its patriarch dies. Meryl Streep would play the drug-addicted matriarch, while Julia Roberts would play the eldest daughter who is estranged from her adulterous husband.
British actress Andrea Riseborough ("W.E.") was also in contention for the part of Karen
Chris Cooper plays Streep's brother in law
John Wells will direct the film from a screenplay adapted by Letts.
Harvey Weinstein and Jean Doumanian will produce the pic.
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