Previously titled "Devil in My Shoes", the story centers on two reckless siblings (Miller, Kate Bosworth) who are dragged to a disastrous family wedding by their mother (Ellen Barkin). Landau and Ellen Burstyn play grandparents.
Demi Moore also stars.
Sam is the 25-year-old son of industry veteran Barry Levinson.
Production begins on the film next week in Michigan.
The plot involves a viral outbreak on the U.S. east coast and mostly focuses on a small town in Maryland. Shooting will be done "Cloverfield " style with a pseudo-documentary, portable camera feel.
Filming is already underway in Georgetown, South Carolina.