Reports say McAvoy left the production "due to unrelated circumstances beyond his control".
E! Online adds from a source that the cause is a family emergency.
Former Cancer co-star Seth Rogen said in a statement:
"it's incredibly unfortunate that circumstances outside of everyone's control have taken James away from the project, but, with James's blessing, we were able to have Joseph step in to take on the role of Adam. We all look forward to working with James in the future."
Director Jonathan Levine: "I feel extremely lucky that our film has found an exceptional actor to step into the role of Adam. I have admired Joseph's work since Brick and I am so excited to work with him."
Anna Kendrick Bryce Dallas Howard,, Anjelica Huston and Philip Baker Hall. also star in the film.
Will Reiser wrote the script based on his personal experiences with this disease in his 20's
Evan Goldberg, Ben Karlin and Rogen are producing the pic
The production has temporarily been shut down but now is set to resume on March 8th
I hope everything goes well for McAvoy
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