Jason Segel and Emily Blunt star in the film which chronicles the highs and lows of a lengthy relationship.
Details regarding Ifans and Pratt's roles are not yet known
Earlier this week Alison Brie was tapped to play Blunt's younger sister.
"Forgetting Sarah Marshall" and "Get Him to the Greek" scribes Segel and Stoller co-wrote the script.
Judd Apatow, Rodney Rothman and Stoller are producing. Shooting kicks off towards the end of next month.
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