The story follows a family named the Winslows who move from Kansas to Orange County with their dog Marmaduke, a slobbery Great Dane who creates chaos wherever he goes.
Tim Rasmussen and Vince Di Meglio's script has Marmaduke navigating a volatile Mutts vs. Pedigrees turf war, wooing the purebred of his dreams and overcoming a fall from grace.
Judy Greer, Lee Pace and William H. Macy are playing humans. Wilson joins Fergie of The Black Eyed Peas Emma Stone, George Lopez Christopher Mintz-Plasse, Steve Coogan, and Damon Wayans and Marlon Wayans will supply the voices to the film's various critters.
Tom Dey (Failure to Launch, Shanghai Noon) will direct the comedy which opens in June.
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